It was the third time in the last five years Harding has defeated a NCAA Division I opponent. The Lady Bisons previous wins came against Lipscomb in 2011 and in 2006.
For the second straight game Harding outrebounded their opponent. HU grabbed 46 to Oral Roberts 34. The Lady Bisons outrebounded Wichita State 32-27 on Sunday in their first exhibition game.
Harding scored eight 3-pointers in the contest. Lewis and Holmes each had two for the Lady Bisons.
Harding hit 18-of-23 free throws (78.3 percent).
Oral Roberts was led by Kevi Luper who had 21 points, hitting 8-of-19 from the field. She also had three 3-pointers.